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KMID : 0191120120270020228
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Journal of Korean Medical Science
2012 Volume.27 No. 2 p.228 ~ p.230
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EML4-ALK Fusion Gene in Korean Non-Small Cell Lung Cancer
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Jin Guang
Jeon Hyo-Sung
Lee Eung-Bae
Kang Hyo-Gyoung
Yoo Seung-Soo
Lee Shin-Yup
Lee Jae-Hee
Cha Sung-Ick
Park Tae-In
Kim Chang-Ho
Jheon Sang-Hoon
Park Jae-Yong
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Abstract
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A fusion gene between echinoderm microtubule-associated protein-like 4 (EML4) and the anaplastic lymphoma kinase (ALK) has been identified in non-small cell lung cancers (NSCLCs). Although a few studies have evaluated EML4-ALK fusion genes in Korean NSCLCs, the prevalence of different EML4-ALK fusion variants has yet to be clearly assessed. Herein, we have examined the profiles of EML4-ALK fusion gene variants in Korean patients of NSCLCs. EML4-ALK fusion genes have been detected in 10 (6.0%) of 167 patients of NSCLCs and in 9 (7.4%) of 121 patients of adenocarcinoma. Of the 10 patients with fusion genes identified, 8 (80%) were E13;A20 (variant 1) and 2 (20%) were E6;A20, with an additional 33-bp sequence derived from intron 6 of EML4 (variant 3b). These results indicate that the profiles of EML4-ALK fusion gene variants in Korean patients of NSCLC may differ from those in other ethnic populations. Herein, we describe for the first time the profiles of EML4-ALK fusion variants of Korean patients with NSCLCs.
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KEYWORD
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ALK, EML4, Carcinoma, Non-Small-Cell Lung
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